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Nocturnal Enuresis and Desmopressin
Pharmacotherapy with desmopressin is a standard treatment option for nocturnal enuresis. Desmopressin is a synthetic form of the human antidiuretic hormone, arginine vasopressin which regulates water retention in the body. Due to its high antidiuretic activity, desmopressin is used for the treatment of nocturnal enuresis and nocturia (night-time urination). It increases water permeability in renal tubular cells, thus reducing urine volume.
Evaluating use of higher dose oxybutynin in combination with desmopressin for refractory nocturnal enuresis
Aaron Berkenwald, Jacqueline Pires, Pamela EllsworthJournal of Pediatric Urology (2016), http://dx.doi.org/10.1016/j.jpurol.2016.05.029
Commented by Konstantinos Kamperis:
This study explores the efficacy of a combination treatment with desmopressin and oxybutynin in children who...
Desmopressin (melt) therapy in children with monosymptomatic nocturnal enuresis and nocturnal polyuria results in improved neuropsychological functioning and sleep.
Van Herzeele C, Dhondt K, Roels SP, Raes A, Hoebeke P, Groen LA, Vande Walle J.Pediatric Nephrology 2016 April 11
The sleep of children suffering from nocturnal enuresis has been in researchers’ focus for decades. Different aspects have...
Desmopressin improves sleep and psychological functioning in patients with monosymptomatic nocturnal enuresis
By C. Van Herzeele, K. Dhondt, A. Raes, A. Groen, S. Roels, P. Hoebeke and J. Vande WalleNeurourology and Urodynamics, Volume 33, Issue 6, August 2014, Pages 849-850
This study adds value to the fact that the sleep quality is impaired in children who sleep in...
Does structured withdrawal of desmopressin improve relapse rates in patients with monosymptomatic enuresis?
By M.I. Gökçe, P. Hajiyev, E. Süer, Y. Kibar, M.S. Silay, S. Gürocak, H.S. Doǧan, H.C. Irkilata, T. Oktar, B. Önal, E. Erdem, Y.C. Aygün, C. Balci, A.R. Arslan, C. Kaya, T. Soygür, Ş. Sarikaya, S. Tekgül, and B. Burgu.Journal of Urology, Volume 192, Issue 2, August 2014, Pages 530-534
An important challenge in the treatment of nocturnal enuresis is the chance of relapse. The authors of this...