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Nocturnal Enuresis and Desmopressin
Pharmacotherapy with desmopressin is a standard treatment option for nocturnal enuresis. Desmopressin is a synthetic form of the human antidiuretic hormone, arginine vasopressin which regulates water retention in the body. Due to its high antidiuretic activity, desmopressin is used for the treatment of nocturnal enuresis and nocturia (night-time urination). It increases water permeability in renal tubular cells, thus reducing urine volume.
Increased renal concentrating ability after long-term oral desmopressin lyophilisate treatment contributes to continued success for monosymptomatic nocturnal enuresis
Hirokazu Ikeda, Tsuneki Watanabe and Keiichi Isoyama - Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Department of Pediatrics, Showa University, Tokyo, JapanInternational Journal of Urology, 2017 Jun 21. doi: 10.1111/iju.13394. [Epub ahead of print]
Kamperis K, Hagstroem S, Faerch M, Mahler B, Rittig S, Djurhuus JCPediatr Nephrol. 2016 Oct 27. [Epub ahead of print]
Evaluating use of higher dose oxybutynin in combination with desmopressin for refractory nocturnal enuresis
Aaron Berkenwald, Jacqueline Pires, Pamela EllsworthJournal of Pediatric Urology (2016), http://dx.doi.org/10.1016/j.jpurol.2016.05.029
Desmopressin (melt) therapy in children with monosymptomatic nocturnal enuresis and nocturnal polyuria results in improved neuropsychological functioning and sleep.
Van Herzeele C, Dhondt K, Roels SP, Raes A, Hoebeke P, Groen LA, Vande Walle J.Pediatric Nephrology 2016 April 11
Desmopressin improves sleep and psychological functioning in patients with monosymptomatic nocturnal enuresis
By C. Van Herzeele, K. Dhondt, A. Raes, A. Groen, S. Roels, P. Hoebeke and J. Vande WalleNeurourology and Urodynamics, Volume 33, Issue 6, August 2014, Pages 849-850
Does structured withdrawal of desmopressin improve relapse rates in patients with monosymptomatic enuresis?
By M.I. Gökçe, P. Hajiyev, E. Süer, Y. Kibar, M.S. Silay, S. Gürocak, H.S. Doǧan, H.C. Irkilata, T. Oktar, B. Önal, E. Erdem, Y.C. Aygün, C. Balci, A.R. Arslan, C. Kaya, T. Soygür, Ş. Sarikaya, S. Tekgül, and B. Burgu.Journal of Urology, Volume 192, Issue 2, August 2014, Pages 530-534