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Pharmacokinetics of desmopressin administered as tablet and oral lyophilisate formulation in children with monosymptomatic nocturnal enuresis

By P. De Bruyne, A. De Guchtenaere, C. Van Herzeele, A. Raes, J. Dehoorne, P. Hoebeke, E. Van Laecke, and J. Vande Walle.

European Journal of Pediatrics, Volume 173, Issue 2, 2014, Pages 223-228

 

Editor’s comments:

Desmopressin 120 μg oral lyophilisate and 200 μg tablet are considered bioequivalent and this study has invesitgated the pharmacokinetics in children of both formula.  No significant difference in plasma concentration of 120 μg desmopressin oral lyophilisate and 200 μg tablet was found, not even with concomitant food intake. A difference in variability was found between desmopressin oral lyophilisate and the tablets, however comparable plasma levels for desmopressin oral lyophilisate where found despite the lower dose. The dosage for desmopressin oral lyophilisate is more predictable due to the significantly smaller variance. Therefore, desmopressin oral lyophilisate seems more suitable, especially in the younger age group for which time interval between dinner and drug administration is limited

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